SIPaKMeD Database

Download images and features

The SIPaKMeD database is publicly available and it can be used for experimental purposes with the request to cite the following paper:
Marina E. Plissiti, Panagiotis Dimitrakopoulos, Giorgos Sfikas, Christophoros Nikou, Olga Krikoni, Antonia Charchanti, SIPAKMED: A new dataset for feature and image based classification of normal and pathological cervical cells in Pap smear images, IEEE International Conference on Image Processing (ICIP) 2018, Athens, Greece, 7-10 October 2018. 
The SIPaKMeD Database consists of 4049 images of isolated cells that have been manually cropped from 966 cluster cell images of Pap smear slides. These images were acquired through a CCD camera adapted to an optical microscope. The cell images are divided into five categories containing normal, abnormal and benign cells.
Cell Categories

  1. Superficial-Intermediate cells - They constitute the majority of the cells found in a Pap test. Usually they are flat with round, oval or polygonal shape cytoplasm stains mostly eosinophilic or cyanophilic. They contain a central pycnotic nucleus. They have well defined, large polygonal cytoplasm and easily recognized nuclear limits (small pycnotic in the superficial and vesicular nuclei in intermediate cells). These type of cells show the characteristics morphological changes (koilocytic atypia) due to more severe lessions.
  2. Parabasal cells - Parabasal cells are immature squamous cells and they are the smallest epithelial cells seen on a typical vaginal smear. The cytoplasm is generally cyanophilic and they usually contain a large vesicular nucleus. It must be noted that parabasal cells have similar morphological characteristic with the cells identified as metaplastic cells and it is difficult to be distinguished from them. 
  3. Koilocytotic cells - These cells correspond most commonly in mature squamous cells (intermediate and superficial) and some times in metaplastic type koilocytotic cells. They appear most often cyanophilic, very lightly stained and they are characterized by a large perinuclear cavity. The periphery of the cytoplasm is very dense stained. The nuclei of koilocytes are usually enlarged, eccentrically located, hyperchromatic and exhibit irregularity of the nuclear membrane contour. 
  4. Dysketarotic cells - They are squamous cells which undergone premature abnormal keratinization within individual cells or more often in three-dimensional clusters. They exhibit a brilliant orangeophilic cytoplasm. They are characterized by the presence of vesicular nuclei, identical to the nuclei of koilcytotic cells. In many cases there are binucleated and/or multinucleated cells.
  5. Metaplastic Cells - They are in essence small or large parabasal-type cells with prominent cellular borders, often exhibiting eccentric nuclei and sometimes containing a large intracellular vacuole. The staining in the center portion is usually light brown and it often differs from that in the marginal portion. Also, there is essentially a darker-stained cytoplasm and they exhibit great uniformity of size and shape compared to the parabasal cells, as their characteristic is the well defined, almost round shape of cytoplasm. 


Description of the SIPaKMeD database and its contents.

Cell Features

Intensity, texture and shape features of the cytoplasm and the nuclei.

Image Features

Features extracted using the
pre-activations of the first fully-connected layer.

Deep Features

Features extracted using the
pre-activations of the last convolutional layer. 

This work was co-financed by the European Union (European Regional Development Fund- ERDF) and Greek national funds through the Operational Program THESSALY- MAINLAND GREECE AND EPIRUS-2007-2013 of the National Strategic Reference Framework (NSRF 2007-2013).